Conformational Analysis of Febrifugines and Halofuginones in Organic Solvents

Shinichi UESATO; Yoshihiro KURODA; Masahiro KATO; Yasuhiro FUJIWARA; Yasunori HASE; Tetsuro FUJITA

doi:10.1248/cpb.46.1

Shinichi UESATO, Yoshihiro KURODA, Masahiro KATO, Yasuhiro FUJIWARA, Yasunori HASE, Tetsuro FUJITA

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Keywords: Plasmodia, Coccidia, anticoccidial agent, febrifugine, halofuginone, AM1 molecular orbital calculation

JOURNAL FREE ACCESS

1998 Volume 46 Issue 1 Pages 1-5

DOI https://doi.org/10.1248/cpb.46.1

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Abstract

The stereostructures of anticoccidial agents, febrifugine and halofuginone, as well as the corresponding cis-isomers, in organic solvents were determined through NMR analyses, isomerization reactions and AM1 molecular orbital calculations.

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