Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
Byung-Sun MINNorio NAKAMURAHirotsugu MIYASHIROKi-Whan BAEMasao HATTORI
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1998 Volume 46 Issue 10 Pages 1607-1612

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Abstract

Two new lanostane-type triterpenes, lucidumol A and ganoderic acid β, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24, 25-dihydroxylanost-8-ene-3, 7-dione and 3β, 7β-dihydroxy-11, 15-dioxolanosta-8, 24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means. The quantitative analyses of 5 fruiting bodies, antlered form and spores of G. lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore. Of the compound isolated, ganoderic acid β, (24S)-lanosta-7, 9(11)-diene-3β, 24, 25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 μM.

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