Naturally Occurring 5-Lipoxygenase Inhibitors. VII. Practical Synthesis of Ardisiaquinones D, E and F

Abstract

The convergent synthesis of ardisiaquinones D (1), E (3) and F (4), isolated as 5-lipoxygenase inhibitors from Ardisia sieboldii, has been achieved efficiently by a cross-coupling reaction via an acetylene between two benzene units bearing appropriate functional groups readily derived from 2, 5-dimethoxy-1, 4-benzoquinone.