Abstract
Three new withanolides, coagulins M, N, and O were isolated from the whole plant of Withania coagulans. Their structures were established as (14R, 17R, 20ζ, 22R)-5α, 6β, 27-trihydroxy-14, 20-epoxy-1-oxo-witha-24-enolide (1), (14R, 17S, 20ζ, 22R)-15α, 17-dihydroxy-14, 20-epoxy-3β-(O-β-D-glucopyranosyl)-1-oxo-witha-5, 24-dienolide (2) and (14R, 20ζ, 22R)-14, 20-dihydroxy-3β-(O-β-D-glucopyranosyl)-1-oxo-witha-5, 24-dienolide (3) respectively, by extensive spectroscopic studies.
