Novel and Simple Syntheses of 5H-Pyrido[4, 3-b]indole (γ-Carboline) Derivatives Having a Methoxycarbonyl Group at the 4-Position Based on 1-Hydroxyindole Chemistry

Masanori SOMEI; Fumio YAMADA; Gaku YAMAMURA

doi:10.1248/cpb.46.191

Masanori SOMEI, Fumio YAMADA, Gaku YAMAMURA

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Keywords: 1-hydroxyindole, 1-methoxyindole-3-carbaldehyde, 5H-pyrido[4, 3-b]indole, dimethyl 2-(3-formylindol-2-yl)malonate, metyl 5H-pyrido[4, 3-b]indole-4-carboxylate, methyl 2, 3-dihydro-3-oxo-5H-pyrido[4, 3-b]indole-4-carboxylate

JOURNAL FREE ACCESS

1998 Volume 46 Issue 2 Pages 191-198

DOI https://doi.org/10.1248/cpb.46.191

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Abstract

A simple synthetic method for 5H-pyrido[4, 3-b]indole (γ-carboline) derivatives having a methoxycarbonyl group at the 4-position was developed based on 1-hydroxyindole chemistry. By applying the method, various 3-substituted metyl 5H-pyrido[4, 3-b]indole-4-carboxylates and 2-substituted methyl 2, 3-dihydro-3-oxo-5H-pyrido[4, 3-b]indole-4-carboxylates were prepared.

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