Abstract
The π values of benzalacetones (BZ) and trans-1, 1, 1-trifluoro-4-phenyl-3-buten-2-ones (TF) with a substituent on the benzene ring were analyzed by the directional Hommett-type treatment. The correlation equation showed that πBZ and πTF values are altered from the π value of monosubstituted benzenes, πPhX, mainly by the change in the hydrogen bonding behavior of the variable substituent caused by the electron-withdrawing fixed substituent. The log k' values for BZ and TF derived from reversed-phase liquid chromatography (RPLC) were correlated with log P values determined by using different compositions of methanol-phosphate buffer (pH 7.4) as eluents. A good linear correlation was obtained at 50% methanol concentration.
