Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A General Method for the Preparation of 5-Trifluoromethylated Oxazoles from α-Amino Acids
Masami KAWASEHiroshi MIYAMAETeruo KURIHARA
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1998 Volume 46 Issue 5 Pages 749-756

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Abstract

The reactions of N-acyl-N-benzyl-α-amino acids (1) or N-acylprolines (5) with trifluoroacetic anhydride in the presence of pyridine afford 5-trifluoromethyloxazoles (2 or 7) in good yields. The reaction could proceed through the transient formation of mesoionic 1, 3-oxazolium-5-olates, followed by oxazolium salts.

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© The Pharmaceutical Society of Japan
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