Structures of Two New 18, 22-Cyclosterols, Emesterones A and B, from Emericella heterothallica

Tomoo HOSOE; Tomohiro SAMESHIMA; Kazuyuki DOBASHI; Ken-ichi KAWAI

doi:10.1248/cpb.46.850

Tomoo HOSOE, Tomohiro SAMESHIMA, Kazuyuki DOBASHI, Ken-ichi KAWAI

著者情報

キーワード: Emericella heterothallica, 18, 22-cycloergostane, emesterone A, emesterone B, Mer-NF8054X, antifungal activity

ジャーナルフリー

1998 年 46 巻 5 号 p. 850-852

DOI https://doi.org/10.1248/cpb.46.850

詳細

抄録

Two new 18, 22-cyclosterols, emesterones A (2) and B (3), were isolated along with Mer-NF8054X (1) from the culture filtrate of Emericella heterothallica. The structures of 2 and 3 were established as 3, 11-dioxo-18, 22-cycloergosta-6, 8(14)-diene-5β, 9β, 23S-triol and 3, 11-dioxo-18, 22-cycloergosta-4, 6, 8(14)-triene-9β, 23S-diol, respectively, on the basis of spectroscopic and chemical investigations. The antifungal activity of emesterone B (3) towards Aspergillus fumigatus was slightly weaker than that of Mer-NF8054X (1).

責任著者(Corresponding author)

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