A Straightforward Preparation of Chiral 5-(Aminomethyl)oxazole Derivatives from α-Amino Esters and α-Lithiated Isocyanides

Abstract

An efficient and general preparation of several chiral N-protected 5-(aminomethyl)oxazoles has been accomplished by treatment of N-protected α-amino esters with α-lithiated isocyanides, obtained by metalation of methyl and benzyl isocyanides with BuLi or of ethyl isocyanide with lithium diisopropylamide.