Structures of New Seven-Membered Ring Vibsane-Type Diterpenes Isolated from Leaves of Viburnum awabuki

Hiroyuki MINAMI; Sayoko ANZAKI; Miwa KUBO; Mitsuaki KODAMA; Kazuyoshi KAWAZU; Yoshiyasu FUKUYAMA

doi:10.1248/cpb.46.1194

Hiroyuki MINAMI, Sayoko ANZAKI, Miwa KUBO, Mitsuaki KODAMA, Kazuyoshi KAWAZU, Yoshiyasu FUKUYAMA

著者情報

キーワード: Viburnum awabuki, Caplifoliaceae, vibsane-type diterpene, seven-membered ring, hydroperoxy group, cytotoxicity

ジャーナルフリー

1998 年 46 巻 8 号 p. 1194-1198

DOI https://doi.org/10.1248/cpb.46.1194

詳細

抄録

Five new vibsane-type diterpenes, vibsanin G, vibsanin H, vibsanin K, 18-O-methylvibsanin K and 15, 18-di-O-methylvibsanin H were isoalted from the leaves of Viburnum awabuki (Caplifoliaceae). Their structures were elucidated by analyses of spectroscopic data involving comparison of their ¹³C-NMR data with those of the previously known vibsanin C, and the structure of vibsanins H and K were confirmed by X-ray crystallographic analysis and chemcial transformation, respectively. All five new compounds differ from the seven-membered ring vibsane-type diterpene, vibsanin C, only in the C-12-C-17 side chain.

責任著者(Corresponding author)

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