Aminoacrylates. II. An Efficient Synthesis of α-Pyridones by Heterocyclic Annelation Reactions of Magnesium Amides Derived from sec-Aminoacrylates with Methyl Propiolate

Takeshi KOIKE; Naoki TAKEUCHI; Seisho TOBINAGA

doi:10.1248/cpb.47.128

Takeshi KOIKE, Naoki TAKEUCHI, Seisho TOBINAGA

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Keywords: aminoacrylate, methyl propiolate, pyridone, magnesium amide, heterocyclic annelation reaction

JOURNAL FREE ACCESS

1999 Volume 47 Issue 1 Pages 128-130

DOI https://doi.org/10.1248/cpb.47.128

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Abstract

The reactions of magnesium amides 4 derived from sec-aminoacrylates 3 and ethylmagnesium bromide with methyl propiolate (2) afforded α-pyridones. This provides an efficient heterocyclic annelation reaction.

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