Effect of Oxygen on the Reaction of Secondary Amines with Nitric Oxide

Takashi ITOH; Yuji MATSUYA; Hiromi MAETA; Michiko MIYAZAKI; Kazuhiro NAGATA; Akio OHSAWA

doi:10.1248/cpb.47.133

Takashi ITOH, Yuji MATSUYA, Hiromi MAETA, Michiko MIYAZAKI, Kazuhiro NAGATA, Akio OHSAWA

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Keywords: nitric oxide, dinitrogen trioxide, nitrosation, N-nitrosamine

JOURNAL FREE ACCESS

1999 Volume 47 Issue 1 Pages 133-135

DOI https://doi.org/10.1248/cpb.47.133

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Abstract

Secondary amines were allowed to react with nitric oxide in the presence of oxygen to afford N-nitrosamines in good yields. Detailed investigation revealed that the reaction proceeded by two pathways; the one involves the catalytic behavior of oxygen, and the other consumes a stoichiometrical amount of oxygen. Both pathways afforded the same nitroso adducts.

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