Synthetic Strategies Towards the Total Synthesis of Phyllanthocin and Breynolide. Application of Stereochemically Linear and Convergent Strategies.

Abstract

Phyllanthoside and breynin A are structurally related spiroketal glycoside natural products with potent, interesting and diverse biological activities. Due to their therapeutic potential and novel architecture, the respective aglycones, phyllanthocin and breynolide have attracted significant effort from the synthetic community. This review highlights the synthetic approaches to these targets with an emphasis on the strategy for incorporating the requisite stereogenic centers.