Synthesis of Cyclic Oligopeptides Containing an Arg-Gly-Asp (RGD) Sequence

Shosuke SOFUKU; Akiko HOSHIDA; Takehiro SHIMADA; Yoichi TAKADA; Takashi TAKAKUWA

doi:10.1248/cpb.47.1799

Shosuke SOFUKU, Akiko HOSHIDA, Takehiro SHIMADA, Yoichi TAKADA, Takashi TAKAKUWA

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Keywords: Arg-Gly-Asp (RGD) sequence, platelet aggregation inhibitor, cyclic peptide, circular dichroism spectrum

JOURNAL FREE ACCESS

1999 Volume 47 Issue 12 Pages 1799-1801

DOI https://doi.org/10.1248/cpb.47.1799

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Abstract

The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthsized by the solution method and their cyclization was performed in high dilution using DPPA.

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