Prostanoids and Related Compounds. VII. Synthesis and Inhibitory Activity of 1-Isoindolinone Derivatives Possessing Inhibitory Activity against Thromboxane A2 Analog (U-46619)-Induced Vasoconstriction

Yoshiaki KATO; Masumi TAKEMOTO; Kazuo ACHIWA

doi:10.1248/cpb.47.529

Prostanoids and Related Compounds. VII. Synthesis and Inhibitory Activity of 1-Isoindolinone Derivatives Possessing Inhibitory Activity against Thromboxane A₂ Analog (U-46619)-Induced Vasoconstriction

Yoshiaki KATO, Masumi TAKEMOTO, Kazuo ACHIWA

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Keywords: 1-isoindolinone derivative, vasorelaxant, thromboxane A₂ analog (U-46619)

JOURNAL FREE ACCESS

1999 Volume 47 Issue 4 Pages 529-535

DOI https://doi.org/10.1248/cpb.47.529

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Abstract

We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A₂ analog.

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