Synthesis of Cancer Peptide Antigen-Lipid A Analog Conjugates for Synthetic Vaccines

Kiyoshi IKEDA; Keisuke MIYAJIMA; Yasufumi MARUYAMA; Kazuo ACHIWA

doi:10.1248/cpb.47.563

Kiyoshi IKEDA, Keisuke MIYAJIMA, Yasufumi MARUYAMA, Kazuo ACHIWA

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Keywords: lipid A analog, mitogenic activity, immunoadjuvant, synthetic vaccine, cancer peptide antigen

JOURNAL FREE ACCESS

1999 Volume 47 Issue 4 Pages 563-568

DOI https://doi.org/10.1248/cpb.47.563

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Abstract

Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoly L-serine-β-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.

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