The Dependence of Catalytic Activities of Secondary Functional β-Cyclodextrins on Cavity Structures

Abstract

Secondary imidazole-appended β-cyclodextrin 5 with a nondistorted cavity synthesized from a novel intermediate 3-amino-3-deoxy-β-cyclodextrin exhibits much greater catalytic activity in the ester hydrolysis than its isomer 6 with a distorted cavity, indicating that the catalytic activities of secondary functional cyclodextrins are dependent on cavity structures.