Synthesis of Alkynyl- and Aryldifluoroacetate Using a Copper Complex from Ethyl Bromodifluoroacetate

Kazuyuki SATO; Ryuichi KAWATA; Fumitaka AMA; Masaaki OMOTE; Akira ANDO; Itsumaro KUMADAKI

doi:10.1248/cpb.47.1013

Kazuyuki SATO, Ryuichi KAWATA, Fumitaka AMA, Masaaki OMOTE, Akira ANDO, Itsumaro KUMADAKI

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Keywords: cross coupling, bromodifluoroacetate, alkenyl iodide, alyl iodide, copper, alkynyldifluoroacetate

JOURNAL FREE ACCESS

1999 Volume 47 Issue 7 Pages 1013-1016

DOI https://doi.org/10.1248/cpb.47.1013

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Abstract

Ethyl bromodifluoroacetate reacted with alkenyl or aryl iodides in the presence of copper powder in dimethyl sulfoxide (DMSO) to give the corresponding alkynyl- or aryldiffuoroacetates in moderated to good yields.

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