12-O-Acetylphorbol-13-decanoate Potently Inhibits Cytopathic Effects of Human Immunodeficiency Virus Type 1 (HIV-1), without Activation of Protein Kinase C

Sahar EL-MEKKAWY; Meselhy R. MESELHY; Norio NAKAMURA; Masao HATTORI; Takuya KAWAHATA; Toru OTAKE

doi:10.1248/cpb.47.1346

Sahar EL-MEKKAWY, Meselhy R. MESELHY, Norio NAKAMURA, Masao HATTORI, Takuya KAWAHATA, Toru OTAKE

著者情報

キーワード: Croton tiglium, phorbol ester, anti-HIV-1, protein kinase C

ジャーナルフリー

1999 年 47 巻 9 号 p. 1346-1347

DOI https://doi.org/10.1248/cpb.47.1346

詳細

抄録

Through bioactivity-guided fractionation, eight phorobol di-esters, including five new ones (1-5), were isolated from the seeds of Croton tiglium collected in Egypt. 12-O-Acetylphorbol-13-decanoate (6) and 12-O-decanoylphorobol-13-(2-methylbutyrate) (4) potently inhibited the HIV-1-induced cytopathic effect on MT-4 cells (IC₁₀₀ values of 7.6 ng/ml and 7.81 μg/ml, and CC₀ values of 62.5μg/ml and 31.3 μg/ml, respectively) without activating protein kinase C.

責任著者(Corresponding author)

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