Isolation of Iso-Grayanotoxin II from Leaves of Leucothoe grayana MAX. Its X-Ray Crystallographic Analysis and Acute Toxicity in Mice

Tadamasa TERAI; Daisuke ARAHO; Kanehiro OSAKABE; Masaaki KATAI; Isao NARAMA; Tetsuro MATSUURA; Jun'ichi KATAKAWA; Tadahiro TETSUMI; Mamoru SATO

doi:10.1248/cpb.48.142

Tadamasa TERAI, Daisuke ARAHO, Kanehiro OSAKABE, Masaaki KATAI, Isao NARAMA, Tetsuro MATSUURA, Jun'ichi KATAKAWA, Tadahiro TETSUMI, Mamoru SATO

著者情報

キーワード: iso-grayanotoxin II, Leucothoe grayana MAX., lethal dosage, X-ray analysis

ジャーナルフリー

2000 年 48 巻 1 号 p. 142-144

DOI https://doi.org/10.1248/cpb.48.142

詳細

抄録

The structure of iso-trayanotoxin II, a new diterpenoid from Leucothoe grayana MAX., has been determined as 3β, 5β, 6β, 14β, 16α-pentahydroxygrayanotox-9(10)-ene by spectroscopic and X-ray crystallographic analysis. The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.

責任著者(Corresponding author)

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