Lipid A and Related Compounds. XXXVII. Determination of Favorable Binding Linkages of Lipid A Analog to Antigen Moiety for Synthetic Vaccines

Kiyoshi IKEDA; Keisuke MIYAJIMA; Tadayosi SHIMIZU; Kazuo ACHIWA

doi:10.1248/cpb.48.32

Lipid A and Related Compounds. XXXVII. Determination of Favorable Binding Linkages of Lipid A Analog to Antigen Moiety for Synthetic Vaccines

Kiyoshi IKEDA, Keisuke MIYAJIMA, Tadayosi SHIMIZU, Kazuo ACHIWA

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Keywords: lipid A analog, mitogenic activity, immunoadjuvant, synthetic vaccine

JOURNAL FREE ACCESS

2000 Volume 48 Issue 1 Pages 32-40

DOI https://doi.org/10.1248/cpb.48.32

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Abstract

For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenicities were examined. Among chemically synthesized compounds (6-15, 30), compound 8 for Type B exhibited the most potent mitogenicity.

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