Synthesis of 15α-Fluoro-24, 25-dihydrolanosterol as a Potential Inhibitor and/or Mechanistic Probe for Lanosterol 14α-Demethylase

抄録

As a potential inhibitor and/or mechanistic probe for lanosterol 14α-demethylase, 15α-fluoro-24, 25-dihydrolanosterol was prepared by fluorination of 15α-hydroxy-24, 25-dihydrolanost-7-en-3β-yl benzoate with diethyl-aminosulfur trifluoride, followed by hydrogen chloride-catalyzed isomerization of the Δ⁷ to Δ⁸ and reductive cleavage of the benzoate.