Sterically Constrained 'Roofed' 2-Thiazolidinones as Excellent Chiral Auxiliaries

抄録

The "roofed" chiral 2-thiazolidinones, which are sterically congested and conformational rigid, and which are perpared by the [4+2] cycloaddition of 2-thiazolone to the cyclic dienes, dimethylanthracene and hexamethylcyclopentadiene, followed by optical resolution with (1S, 2R)-2-methyoxy-1-apocamphanecarbonic acid (MAC acid) are of considerable promise for use as chiral auxiliaries for the alkylation of enolates.