A Practical Synthesis of the ABC Ring Model of Ecteinascidins
2000 年 48 巻 10 号 p. 1549-1557
詳細
2000 年 48 巻 10 号 p. 1549-1557
A practical synthesis of 1, 2, 3, 4, 5, 6-hexahydro-1, 5-imino-10-hydroxy-9-methoxy-3, 8, 11-trimethyl-3-benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%.
