Studies on the Synthesis of Myriaporones : Stereoselective Synthesis of the C5-C13 Fragment Starting from D-Glucose via Regioselective Reductive Opening of Methoxybenzylidene Acetal

Abstract

A stereoselective synthesis is described of the C5-C13 fragment (4) of myriaporone 4 (1) starting from D-glucose by a coupling of the C5-C9 aldehyde (5), prepared using a regioselective reductive ring-opening of methoxy-benzylidene acetal, with the C10-C13 iodoolefin (6).