A New Synthesis of Indoloquinolizines by Pictet-Spengler Reaction of Tryptamine Type 1, 2-Dihydropyridines Utilizing sec-Nitrodienamine

Takeshi KOIKE; Yoshifumi SHINOHARA; Seisho TOBINAGA; Naoki TAKEUCHI

doi:10.1248/cpb.48.1898

Takeshi KOIKE, Yoshifumi SHINOHARA, Seisho TOBINAGA, Naoki TAKEUCHI

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Keywords: nitrodienamine, tryptamine, 1, 2-dihydropyridine derivative, indoloquinolizine, Pictet-Spengler reaction

JOURNAL FREE ACCESS

2000 Volume 48 Issue 12 Pages 1898-1902

DOI https://doi.org/10.1248/cpb.48.1898

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Abstract

The Pictet-Spengler reaction of tryptamine type 1, 2-dihydropyridine 5c derived from the cycloaddition of the sec-nitrodienamine 3c with acetaldehyde afforded the indoloquinolizine derivatives 6 and 7.

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