New Access to 7, 17-Seco Norditerpenoid Alkaloids via Reduction of the Corresponding 8-Chloro Derivatives

Feng-Peng WANG; Jin-Song YANG; Qiao-Hong CHEN; Lin YU; Bo-Gang LI

doi:10.1248/cpb.48.1912

Feng-Peng WANG, Jin-Song YANG, Qiao-Hong CHEN, Lin YU, Bo-Gang LI

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Keywords: norditerpenoid alkaloid, 7, 17-seco norditerpenoid alkaloid, yunnaconitine, isotalatizidine

JOURNAL FREE ACCESS

2000 Volume 48 Issue 12 Pages 1912-1916

DOI https://doi.org/10.1248/cpb.48.1912

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Abstract

New access to the 7, 17-seco norditerpenoid alkaloids 9 (60%) from yunnaconitine (5), as well as 14 (46%) and 15 (22%) from isotalatizidine (10), via selective hydrolysis, chlorination and reduction with NaBH₄ is described.

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