2000 年 48 巻 12 号 p. 1973-1977
We recently proposed a new H-accepting scale, SHA, for monosubstituted pyrazines, and demonstrated that this parameter works effectively in expressing the relationship between log P (P : 1-octanol/water partition coefficient) and log k' (k' : retention factor derived from reversed phase liquid chromatography) with aqueous methanol solutions as the mobile phase, according to the equation : log k'=α log P+ρσI+sSHA+const., where σI represents the electronic substituent constant. In this work, we have extended the same treatment to analysis of log k' measured in mobile phases containing different organic modifiers such as 1-propanol, acetonitrile, and dioxane, and found that the above equation is still useful. By comparing the correlations obtained, it was confirmed that parameter SHA could be universally utilized for representing the difference in H-bonding effects involved in different partitioning systems.