Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Trifluoromethanesulfonic Anhydride-Promoted α-Bromination of Ketones with Grignard Reagent or Magnesium Bromide
Tomihiro NISHIYAMAYasuhiro ONOSachiko KUROKAWASaori KIMURA
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JOURNAL FREE ACCESS

2000 Volume 48 Issue 12 Pages 1999-2002

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Abstract
The direct α-bromination of various ketones using trifluoromethanesulfonic anhydride and Grignard reagent or magnesium bromide in ether gave the corresponding α-bromo ketones in moderate to good yields under mild reaction conditions.
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© The Pharmaceutical Society of Japan
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