Abstract
Two bisquinoline derivatives, N, N'-bis(2-quinolylmethyl)ethylenediamine (2-BQME) and N, N'-bis(8-quinolylmethyl)ethylenediamine (8-BQME) have been synthesized, and their ability to bind to duplex DNA was studied. 8-BQME bound to DNA more strongly than 2-BQME, judging from the extent of increase in the melting temperature of duplex DNA, the UV-vis spectral change, and ethidium displacement assay. These compounds exhibited apparent AT-specificity suggesting minor groove binding in addition to intercalation.
