Michael-type Reaction of Ethyl Bromodifluoroacetate with α, β-Unsaturated Carbonyl Compounds in the Presence of Copper Powder

Kazuyuki SATO; Misato TAMURA; Kei TAMOTO; Masaaki OMOTE; Akira ANDO; Itsumaro KUMADAKI

doi:10.1248/cpb.48.1023

Kazuyuki SATO, Misato TAMURA, Kei TAMOTO, Masaaki OMOTE, Akira ANDO, Itsumaro KUMADAKI

著者情報

キーワード: bromodifluoroacetate, copper, α, β-unsaturated carbonyl compound, Michael acceptor, 1, 4-addition, δ-oxodifluoroacetate

ジャーナルフリー

2000 年 48 巻 7 号 p. 1023-1025

DOI https://doi.org/10.1248/cpb.48.1023

詳細

抄録

We have reported that the reaction of ethyl bromodifluoroacetate (1) with alkenyl iodides in the presence of copper powder gives ethyl alkenyldifluoroacetates. As an extension of this reaction, reaction of 1 with Michael acceptors in the Presence of copper powder was examined and found to give 1, 4-addition products selectively, unless the acceptor has a group stabilizing a radical intermediate, such as a phenyl group.

責任著者(Corresponding author)

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