Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
Byung-Sun MINJiang-Jing GAONorio NAKAMURAMasao HATTORI
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2000 Volume 48 Issue 7 Pages 1026-1033


Six new highly oxygenated lanostane-type triterpenes, called ganoderic acid γ(1), ganoderic acid δ(2), ganoderic acid ε(3), ganoderic acid ζ(4), ganoderic acid η(5) and ganoderic acid θ(6), were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D (7) and ganoderic acid C2 (8). Their structures of the new triterpenes were determined as (23S)-7β, 15α, 23-trihydroxy-3, 11-dioxolanosta-8, 24(E)-diene-26-oic acid (1), (23S)-7α, 15α, 23-trihydroxy-3, 11-dioxolanosta-8, 24(E)-diene-26-oic acid (2), (23S)-3β, 7β, 23-trihydroxy-11, 15-dioxolanosta-8, 24(E)-diene-26-oic acid (3), (23S)-3β, 23-dihydroxy-7, 11, 15-trioxolanosta-8, 24(E)-diene-26-oic acid (4), (23S)-3β, 7β, 12β, 23-tetrahydroxy-11, 15-dioxolanosta-8, 24(E)-diene-26-oic acid (5) and (23S)-3β, 12β, 23-trihydroxy-7, 11, 15-trioxolanosta-8, 24(E)-diene-26-oic acid (6), respectively, by chemical and spectroscopic means, which included the determination of a chiral center in the side chain by a modification of Mosher's method. The cytotoxicity of the compounds isolated from the Ganoderma spores was carried out in vitro against Meth-A and LLC tumor cell lines.

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