2000 年 48 巻 7 号 p. 1097-1100
The α, α-gem-difluorination of 2', 4'-difluoro-α-(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2', 4', α, α-tetrafluoro α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem-difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).