Synthesis of Diaryl-Substituted Imidazo[1, 2-a]pyridines Designed as Potential Aromatase Inhibitors

Cecile ENGUEHARD; Jean-Louis RENOU; Hassan ALLOUCHI; Jean-Michel LEGER; Alain GUEIFFIER

doi:10.1248/cpb.48.935

Cecile ENGUEHARD, Jean-Louis RENOU, Hassan ALLOUCHI, Jean-Michel LEGER, Alain GUEIFFIER

著者情報

キーワード: non-steroidal P450 aromatase inhibitors, imidazo[1, 2-a]pyridine, synthesis, crystal structure

ジャーナルフリー

2000 年 48 巻 7 号 p. 935-940

DOI https://doi.org/10.1248/cpb.48.935

詳細

抄録

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1, 2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.

責任著者(Corresponding author)

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