Four Mono-tetrahydrofuran Ring Acetogenins, Montanacins B-E, from Annona montana

Li-Quan WANG; Norio NAKAMURA; Meselhy R. MESELHY; Masao HATTORI; Wei-Min ZHAO; Kin-Fai CHENG; Ren-Zhou YANG; Guo-Wei QIN

doi:10.1248/cpb.48.1109

Li-Quan WANG, Norio NAKAMURA, Meselhy R. MESELHY, Masao HATTORI, Wei-Min ZHAO, Kin-Fai CHENG, Ren-Zhou YANG, Guo-Wei QIN

Author information

Li-Quan WANG
Norio NAKAMURA
Meselhy R. MESELHY
Masao HATTORI
Wei-Min ZHAO
Kin-Fai CHENG
Ren-Zhou YANG
Guo-Wei QIN
Author's Organization：
Shanghai Institute of Materia Medica, Chinese Academy of Sciences:Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Department of Chemistry, The University of Hong Kong
South China Institute of Botany, Chinese Academy of Sciences
Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Keywords: acetogenins, Annona montana, Annonaceae, montanacins B-E

JOURNAL FREE ACCESS

2000 Volume 48 Issue 8 Pages 1109-1113

DOI https://doi.org/10.1248/cpb.48.1109

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Abstract

Four novel mono-tetrahydrofuran (THF) acetogenins, montanacins B-E (1-4), were isolated from the ethanolic extract of the leaves of Annona montana. The structures of 1-4 were established by spectroscopic methods and their absolute stereochemistries were determined by the advanced Mosher ester method. Montancins D (3) and E (4) bear a non-adjacent tetrahydropyran (THP) ring along with a THF ring and are the most unusual type of acetogenins discovered so far.

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