Major Metabolites of Ginseng Sapogenins formed by Rat Liver Microsomes

Ryoji KASAI; Kazumasa HARA; Rumiko DOKAN; Noriko SUZUKI; Tohru MIZUTARE; Shin'ichi YOSHIHARA; Kazuo YAMASAKI

doi:10.1248/cpb.48.1226

Ryoji KASAI, Kazumasa HARA, Rumiko DOKAN, Noriko SUZUKI, Tohru MIZUTARE, Shin'ichi YOSHIHARA, Kazuo YAMASAKI

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Keywords: microsomal metabolite, ginsenoside, 20(S)-protopanaxatriol, 20(S)-protopanaxatriol oxide, 20(S)-protopanaxadiol, 20(S)-protopanaxadiol oxide

JOURNAL FREE ACCESS

2000 Volume 48 Issue 8 Pages 1226-1227

DOI https://doi.org/10.1248/cpb.48.1226

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Abstract

Incubation of ginseng sapogenins with microsomes from rat liver resulted in formation of their 20, 24-epoxides as major metabolites. Identification of the metabolites was performed by HPLC, FAB-MS and EI-MS.

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