Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Taxane Diterpenoids from Seeds of Taxus mairei
Ya-Ching SHENChing-Yeu CHENMeng-Chieh HUNG
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2000 年 48 巻 9 号 p. 1344-1346

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抄録
A new 2(3→20) abeotaxane, taxumairone A (1), and a new cis-p-coumaroyl myo-inositol have been isolated from the seeds of Taxus mairei in addition to taxin B (2), taxinine A, taxuspine X, decinnamoyltaxinine E, 5α-cinnamoyloxy-9α, 10β, 13α-triacetoxy-taxa-4(20)11-diene and 5α-cinnamoyloxy-2α, 9α, 10β, 13α-tetraacetoxy-taxa-4(20)11-diene. The structure of 1 was determined by 2D-NMR spectral analysis and chemical correlation with taxin B (2). Compound 1 exhibited potent cytotoxicity against human colon carcinoma cells with an ED50 of 0.1 μg/ml.
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© The Pharmaceutical Society of Japan
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