Studies on Carcinostatic Substances. XVIII. Anticancer Action of N, N'-Bis (2-chloroethyl)-N, N'-dimethylpolymethylenediamines.

Abstract

Preparation, chemical properties, and carcinostatic activity on the Yoshida sarcoma of N, N'-bis(2-chloroethyl)-N, N'-dimethylpolymethylenediamines were discussed. It was concluded that the derivatives of hexamethylenediamine and nonamethylenediamine were more promising than the corresponding lower homologs with respect to chemotherapeutic indices.