Abstract
A series of 1-tert-alkyl-6, 7-dimethoxy-3, 4-dihydroisoquinolines was synthesized in high yields by cyclizing N-(3, 4-dimethoxyphenethyl)-2, 2, 2-trialkylacetamides with phosphoryl chloride. They were dehydrogenated over palladium-carbon only under strenuous conditions to furnish the corresponding isoquinolines. Their spasmolytic activity will be examined. A general procedure for the preparation of trialkylacetic acids of high purity was also described.
