Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.
Hisashi NogamiManabu Hanano
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1958 Volume 6 Issue 3 Pages 249-255

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Abstract
1. The percutaneous absorption of salicylic acid from several solutions was influenced by the material incorporated in it. The largest obstructive effect was shown in the case of polyethylene glycol 400 and Carbowax 6000. The same effect was shown in propylene glycol and glycerol, and the effect of propylene glycol was larger than that of glycerol. Glucose did not show any effect. The absorption decreased with concentration of the material which showed a pronounced obstructive effect. 2. Degrees of absorption from various aqueous solutions were parallel to the degree of partition between benzene and their solution. 3. Effect of viscosity and surface tension on abosorption was not shown within the region of this experiment.
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© The Pharmaceutical Society of Japan
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