Reaction of 4-methylnicotinic acid with formaldehyde or acetaldehyde gave a lactone, which was led to the amide, and this was oxidized to 1-hydroxy-2, 7-naphthyridine. 2, 7-Naphthyridine and 3-methyl-2, 7-naphthyridine were synthesized from 1-hydroxy derivatives via 1-chloro and 1-hydrazino compounds.
