Studies on Decomposition and Stabilization of Drugs in Solution. II. Chemical Kinetic Studies on Aqueous Solution of Methantheline Bromide.

抄録

1. It was evidenced by the ultraviolet absorption spectral analyses that the decomposition of Methantheline Bromide (M.B.) in aqueous solution was the hydrolysis of ester linkage. 2. The determination of M.B. was carried out separating from its decomposed substances by the colorimetric procedure using ethylene dichloride as a solvent, bromocresol purple as a complexing dye, in a buffer solution of pH 6.5. 3. The decomposition was recognized as a first-order reaction at any given pH value and the reaction was catalyzed by hydrogen ion, hydroxyl ion, and water. The constants were determined as follows : [numerical formula] [numerical formula]