Abstract
The reaction of 2, 4-dimercapto-5-aminopyrimidine with acetic anhydride and benzoyl chloride gave 2-methyl-5-mercapto-(VII) and 2-phenyl-5-mercaptothiazolo [5, 4-d] pyrimidine, respectively. By desulfurization of (VII) with Raney nickel, 2-methylthiazolo [5, 4-d] pyrimidine was obtained. The corresponding thiazolo [5, 4-d] pyrimidines were prepared from 2-ethylthio-4-hydroxy-5-acylamidopyrimidine in the presence of phosphorus pentasulfide.
