Reduction of Substituted Resorcinols. IV. Synthesis of 2-Carbamoyl-4-dimethylaminocyclohexane-1, 3-dione and Related Compounds.

抄録

Under the assumption that the characteristic A-ring in the tetracyclines was responsible for the remarkable antibacterial activity of these antibiotics, syntheses of the A-ring and related compounds were undertaken to examine relationship between chemical structure and antibacterial activity. Following the syntheses of 4-benzamido-, 4-dimethylamino-, and 2-carbamoyl-cyclohexane-1, 3-dione and their derivatives, the A-ring itself of the tetracyclines, 2-carbamoyl-4-dimethylaminocyclohexane-1, 3-dione, and its derivatives were prepared.