Studies on the Metabolism of Naturally Occurring Coumarins. IV. Urinary Metabolites of Dimethylesculetin and Scopoletin.

Abstract

Dimethylesculetin was demethylated in the rabbit to give esculetin 7-methyl ether, scopoletin, and esculetin. The free and conjugated forms of each metabolite were determined directly by a densitometer applied on the paper chromatogram. The urinary metabolites obtained from scopoletin have also been examined.