Abstract
Expecting an antagonistic activity upon nucleic acid metabolism, several kinds of pyrimidine derivatives were synthesized, of which 5-phenylazopyrimidines were found to have growth-inhibitory activity against some microorganisms. With consideration for their biological activities, 31 kinds of 5-phenylazopyrimidine derivatives were synthesized by either of two methods according to the kind of substituents to be introduced into the pyrimidine ring ; benzenediazonium salts were coupled with pyrimidine derivatives at the 5-position in one method, and phenylazo-β-dicarbonyl compounds were condensed with guanidine or acetamidine in the other.
