Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Nucleic Acid Antagonists. IV. Inhibitory Effect of 5-Phenylazopyrimidines on the Enzymatic Conversion of Folic Acid to Citrovorum Factor in vitro.
Minoru Kawashima
Author information
JOURNAL FREE ACCESS

1959 Volume 7 Issue 1 Pages 17-22

Details
Abstract
Examinations were made on the inhibitory action of two groups of 5-phenylazopyrimidines, which were classified on the basis of their antagonistic pattern on Str. faecalis, on enzymatic conversion of folic acid to the citrovorum factor by supernatant solutions of chickliver homogenates. It was demonstrated that the compounds which belong to the first group inhibited the enzymatic conversion of folic acid to the citrovorum factor by interfering in the enzymatic formation of FAH4, but the compounds of the second group exerted no influence on CF conversion.
Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top