抄録
Properties and compositions, as well as the dissociation constants of the copper chelates of α-hydroxyphenazine derivatives, which possess CH3 or COOH group at the α- or β-position, have been investigated by spectrophotometric method. The COOH group peri to a ring-nitrogen is also capable of forming a chelate, and copper chelate of pherazine-1-carboxylic acid has also been studied. In concluding this study of the series of copper chelates of α-hydroxyphenazine derivatives, some findings on the mode of action were made from the standpoint of chelate chemistry. 1) The fortifying effect by copper is caused by the formation of chelate compounds, which are required to possess at least one oxine-like functional group at the α-position. 2) Di-N-oxide derivatives are fairly effective. 3) Introduction of lipophilic radical strengthens the effect. 4) The antibacterial effects depend upon the degree of the binding power between phenazine derivatives and copper.
