Steroid Studies. XII. On the Methylation of 3-Oxosteroids. (2).
1959 年 7 巻 2 号 p. 238-240
詳細
1959 年 7 巻 2 号 p. 238-240
Formylation of progesterone (I) gives the 2, 21-bis (hydroxymethylene) compound (II) and 2-hydroxymethylene compound (III). Methylation of (III) and subsequent deformylation affords 2α-methylprogesterone (V). Formylation of the 5α-dihydro compound (VIII) of (I) results in the sole formation of the 2-hydroxymethylene compound (IX), and its methylation followed by deformylation gives the 2α-methyl derivative (VI). On the contrary, the 5β-dihydro compound (X) of (I) affords only the 4, 21-bis (hydroxymethylene) compound (XI).
