Thirty-one new 2-cyano-3-(5-nitro-2-furyl) acrylamides and esters were synthesized by condensation of 2-cyano-3-(5-nitro-2-furyl) acryloyl chloride and various amines and alcohols. Unexpectedly, these derivatives did not show the desired antibacterial activity in vitro. It seemed that this might be due to a small solubility of these derivatives in water.
